Publication

2024

Shen C.H., Komi Y., Nakagawa Y., Kamatari Y., Nomura T., Kimura H., Shida T., Burke J., Tamai S., Ishida Y., Tanaka M. Exposed Hsp70-binding site impacts yeast Sup35 prion disaggregation and propagation. Proc. Natl. Acad. Sci. U. S. A., in press.

2023

Suryawanshi N., Tanaka M. DISC1 protein aggregates in cerebrospinal fluid as a potential diagnostic biomarker for first-episode psychosis. Psychiatry Clin. Neurosci., in press

Endo R., Chen Y.K., Burke J., Takashima N., Suryawanshi N., Hui K.K., Miyazaki T., Tanaka M. Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3. Proc. Natl. Acad. Sci. U. S. A., 120, e2211522120 (2023).

2022

Raspadori A., Vignali V., Murello A., Giachin G., Samorì B., Tanaka M., Bustamante C., Zuccheri G., Legname G. Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy. Biology (Basel), 16, 1358 (2022).

Hui K.K., Chater T.E., Goda Y., Tanaka M. How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders. Front. Mol. Neurosci., 15, 893111 (2022).

Nakagawa Y., Shen C-h,, Komi Y., Sugiyama S., Kurinomaru T., Tomabechi Y., Krayukhina E., Okamoto K., Yokoyama T., Shirouzu M., Uchiyama S., Inaba M., Niwa T., Sako Y., Taguchi H., Tanaka M. Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system. Nat. Chem. Biol., 18, 321-331 (2022).

Jaaro-Peled H., Kumar S., Hughes D., Sumitomo A., Kim S.H., Zoubovsky S., Hirota-Tsuyada Y., Zala D., Bruyere J., Katz B.M., Huang B., Flores R. 3rd, Narayan S., Hou Z., Economides A.N., Hikida T., Wetsel W.C., Deisseroth K., Mori S., Brandon N.J., Tanaka M., Ishizuka K., Houslay M.D., Saudou F., Dzirasa K., Sawa A., Tomoda T. Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit. Mol. Psychiatry (2022).

Hui, K.K., Endo, R., Sawa, A., and Tanaka, M. A perspective on the potential involvement of impaired proteostasis in neuropsychiatric disorders. Biol. Psychiatry, 91, 335-345 (2022).

2021

Nagayoshi Y., Chujo T., Hirata S., Nakatsuka H., Chen CW., Takakura M., Miyauchi K., Ikeuchi Y., Carlyle B.C., Kitchen R.R., Suzuki T., Katsuoka F., Yamamoto M., Goto Y., Tanaka M., Natsume K., Nairn A.C., Suzuki T., Tomizawa K., Wei F.Y. Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability. Science Adv., 7(13), eabf3072 (2021).

2020

Shida T., Kamatari Y.O.*, Yoda T.*, Yamaguchi Y., Feig M., Ohhashi Y., Sugita Y., Kuwata K., and Tanaka M. Short disordered protein segment regulates cross-species transmission of a yeast prion. Nat. Chem. Biol., 16, 756-765 (2020) (cover).

Endo, R., Takashima, N., Tanaka, M. Abnormal Local Translation in Dendrites Impairs Cognitive Functions in Neuropsychiatric Disorders. In: Toyama, Y., Miyawaki, A., Nakamura, M., Jinzaki, M. (eds) Make Life Visible, 179-186, Springer, Singapore (2020).

2019

Hui, K.K., Chen, Y.*, Endo, R.*, Tanaka, M. Translation from the ribosome to the clinic: Implication in neurological disorders and new perspectives from recent advances. Biomolecules, 9(11), 680 (2019). Invited review. *equal contributions

Hui, K.K., Tanaka., M. Autophagy links MTOR and GABA signaling in the brain. Autophagy, 15(10), 1848-1849 (2019).

Sugiyama, S., Tanaka., M. Distinct segregation patterns of yeast cell-peripheral proteins uncovered by a method for protein segregatome analysis. Proc. Natl. Acad. Sci. U. S. A., 116, 8909-8918 (2019).

Hui, K.K., Takashima, N., Watanabe, A., Chater, T.E., Matsukawa, H., Nekooki-Machida, Y., Nilsson, P., Endo, R., Goda, Y., Saido, T.C., Yoshikawa, T., Tanaka., M. GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA_A receptor trafficking and social behavior. Science Adv., 5(4), eaau8237 (2019).

2018

Endo, R., Takashima, N., Nekooki-Machida, Y., Komi, Y., Hui, K.K., Takao, M., Akatsu, H., Murayama, S., Sawa, A., and Tanaka, M. TDP-43 and DISC1 Co-Aggregation Disrupts Dendritic Local Translation and Mental Function in FTLD. Biol. Psychiatry, 84, 509-521 (2018).

Chen, C.W., Tanaka, M. Genome-Wide Translation Profiling by Ribosome-Bound tRNA Capture. Cell Reports, 23, 608-621 (2018).

Ohhashi Y., Yamaguchi Y., Kurahashi H., Kamatari Y.O., Sugiyama S., Uluca B., Piechatzek T., Komi Y., Shida T., Müller H., Hanashima S., Heise H., Kuwata K, and Tanaka M. Molecular basis for diversification of yeast prion strain conformation, Proc. Natl. Acad. Sci. U. S. A., 115, 2389-2394 (2018).

2017

Tanaka, M., Ishizuka, K., Nekooki-Machida, Y., Endo, R., Takashima, N., Sasaki, H., Komi, Y., Gathercole, A., Huston, E., Ishii, K., Hui, K.K., Kurosawa, M., Kim, S.H., Nukina, N.,Takimoto, E., Houslay, M.D., Sawa, A. Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease. J. Clin. Invest., 127, 1438-50 (2017)

2016

Toyoshima, M., Akamatsu, W., Okada, Y., Ohnishi, T., Balan, S., Hisano, Y., Iwayama, Y.,Toyota, T., Matsumoto, T., Itasaka, N., Sugiyama, S., Tanaka, M., Yano, M., Dean, B., Okano, H., Yoshikawa, T. Analysis of induced pluripotent stem cells carrying 22q11.2 deletion. Transl. Psychiatry, 6, e934 (2016)

2015

Suzuki, G., Weissman, J.S. and Tanaka, M. [KIL-d] protein element confers antiviral activity via catastrophic viral mutagenesis. Mol. Cell, 60, 651-660 (2015).

Tanaka, M. and Komi, Y. Layers of structure and function in protein aggregation. Nat. Chem. Biol., 11, 373-377 (2015).

2014

Nilsson, P., Sekiguchi, M., Akagi, T., Izumi, S., Komori, T., Hui, K., Sörgjerd, K., Tanaka, M., Saito, T., Iwata, N., Saido, T.C. Autophagy-related protein 7 deficiency in APP transgenic mice decreases Aβ in multivesicular bodies and induces Aβ accumulation in the Golgi. Am. J. Pathol., 185(2), 305-13 (2015).

Sugiyama, S. and Tanaka, M. Self-propagating amyloid as a critical regulator for diverse cellular functions. J. Biochem, 155, 345-351 (2014).

2013

Nilsson, P., Loganathan, K., Sekiguchi, M., Matsuba, Y., Hui, K., Tsubuki, S., Tanaka, M., Iwata, N., Saito, T., and Saido, T.C. Aβ secretion and plaque formation depend on autophagy. Cell Reports, 5, 61-69 (2013).

Suzuki, G. and Tanaka, M. Active conversion to the prion state as a molecular switch for cellular adaptation to environmental stress. Bioessays, 35, 12-16 (2013).

Suzuki, G. and Tanaka, M. Expanding the yeast prion world: Active prion conversion of non-glutamine/asparagine-rich Mod5 for cell survival. Prion, 7, 109-113 (2013).

2012

Suzuki, G., Shimazu, N., and Tanaka, M. A Yeast Prion, Mod 5, Promotes Acquired Drug Resistance and Cell Survival Under Environmental Stress. Science 336, 355-359 (2012).

2011

Tanaka, M. Tracking a toxic polyglutamine epitope. Nat. Chem. Biol. 7, 861-862 (2011).
Tonoki, A., Kuranaga, E., Ito, N., Nekooki-Machida, Y., Tanaka, M., and Miura, M. Aging causes distinct characteristics of polyglutamine amyloids in vivo. Genes Cells 16, 557-564 (2011).
Foo, C.K., Ohhashi, Y., Kelly, M.J., Tanaka, M., and Weissman, J.S. Radically Different Amyloid Conformations Dictate the Seeding Specificity of a Chimeric Sup35 Prion. J. Mol. Biol. 408, 1-8 (2011).

2010

Ohhashi, Y., Ito, K., Toyama, B.H., Weissman, J.S., and Tanaka M. Differences in prion strain conformations result from non-native interactions in a nucleus. Nat. Chem. Biol. 6, 225-230 (2010).
Tanaka, M. A protein transformation protocol for introducing yeast prion particles into yeast. Methods in Enzymology (Guide to Yeast Genetics: Functional Genomics, Proteomics and Other Systems Analysis), 470, 681-693 (2010).

2009

Nekooki-Machida, Y., Kurosawa, M., Nukina, N., Ito, K., Oda, T., and Tanaka, M. Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity. Proc. Natl. Acad. Sci. U. S. A., 106, 9678-9684(2009).

2008

McDobald, M., Kendall, A., Tanaka, M., Weissman, J.S., and Stubbs, G. Enclosed chambers for humidity control and sample containment in fiber diffraction. J. Appl. Cryst.,41, 206-209 (2008).

~2007 (selected publications)

Krzewska, J., Tanaka, M., Burston, S.G., and Melki, R. Biochemical and functional analysis of the assembly of full-length Sup35p and its prion-forming domain. J. Biol. Chem., 282, 1679-1686 (2007).
Tanaka, M., Collins, S.R., Toyama, B.H., and Weissman, J.S. The Physical Basis of How Prion Conformations Determine Strain Phenotypes. Nature, 442, 585-589 (2006).
Tanaka, M., Chien, P., Yonekura, K., Weissman, J.S. Mechanism of cross-species prion transmission: An infectious conformation compatible with two highly divergent yeast prion proteins. Cell 121, 49-62 (2005).
Tanaka, M., Machida, Y., and Nukina, N. A novel therapeutic strategy for polyglutamine diseases by stabilizing aggregation-prone proteins with small molecules. J. Mol. Med. 83, 343-352 (2005).
Tanaka, M., Chien, P., Naber, N., Cooke, R., and Weissman, J.S. Conformational Variations in an Infectious Protein Determine Prion Strain Differences. Nature 428, 323-328 (2004).
Venkatraman, P. Wetzel, R. Tanaka, M., Nukina, M., and Goldberg, A.L. Eukaryotic Proteasomes Cannot Digest Polyglutamine Sequences and Release Them Intact during Degradation of Polyglutamine-Containing Proteins. Mol. Cell 14, 95-104 (2004).
Tanaka, M., Machida, Y., Niu, S., Ikeda, T., Jana, N.R., Doi, H., Kurosawa, M., Nekooki, M., and Nukina, N. Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat. Med. 10, 148-154 (2004).
Tanaka, M., Machida, Y., Nishikawa, Y., Akagi, T., Hashikawa, T., Fujisawa, T. and Nukina, N. Expansion of polyglutamine induces the formation of quasi-aggregate in the early stage of protein fibrillization. J. Biol. Chem. 278, 34717–34724 (2003).
Tanaka, M., Matsuura, K., Yoshioka, S., Takahashi, S., Ishimori, K., Hori, H., and Morishima, I. Activation of Hydrogen Peroxide in Horseradish Peroxidase Occurs within approximately 200μs Observed by a New Freeze-Quench Device. Biophys. J. 84, 1998-2004 (2003).

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