Outline
We are investigating the molecular basis of neurodegenerative disorders and psychiatric diseases using both in vivo and in vitro systems via a variety of techniques including neurobiology, structural biology, genetics and proteomics. In conjunction, we are seeking to uncover the structural basis of yeast prion strains and transmission barriers, and to identify novel functional prions or protein aggregates that play physiological roles in cells.
Press Releases
| 2022.02.18 |  |
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| Reconstituted yeast prion propagation -Disaggregation mechanism depends on amyloid conformation– |
News & Views Picturing protein disaggregation |
RIKEN Research News (2022.5.26) Three chaperones coordinate the breakup of amyloid fibrils in yeast |
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| 2019.04.26 |  |
| Protein segregatome analysis during yeast cell division －A new mechanism for septin-dependent cell compartmentalization－ |
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| 2019.04.11 |  |
| Protein pileup affects social behaviors through altered brain signaling −Sequestration of GABARAPs by p62+ aggregates disrupts social behavior |
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| 2018.06.14 |  |
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| Social deficits caused by protein co-aggregation Co-aggregation between TDP-43 and DISC1 impairs local translation in dendrites− |
Biological Psychiatry Press Release (2018.5.8) A new mechanism for neurodegeneration in a form of dementia |
Biological Psychiatry Commentary (2018.10.1) Disrupted in Dementia |
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| 2018.04.11 |  |
| Development of a tRNA ribosome profiling technology －Ribo-tRNA-seq reveals a novel mechanism of translation inhibition－ |
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| 2018.03.22 |  |
| Molecular basis for diversification of amyloid conformation －Structural fluctuation of monomeric protein determines amyloid conformation－ |
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