Outline
We are investigating the molecular basis of neurodegenerative disorders and psychiatric diseases using both in vivo and in vitro systems via a variety of techniques including neurobiology, structural biology, genetics and proteomics. In conjunction, we are seeking to uncover the structural basis of yeast prion strains and transmission barriers, and to identify novel functional prions or protein aggregates that play physiological roles in cells.
Press Releases
| 2018.06.14 |  |
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| Social deficits caused by protein co-aggregation −Co-aggregation between TDP-43 and DISC1 impairs local translation in dendrites− |
Biological Psychiatry Press Release (2018.5.8) A new mechanism for neurodegeneration in a form of dementia |
Biological Psychiatry Commentary (2018.10.1) Disrupted in Dementia |
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| 2018.04.11 |  |
| Development of a tRNA ribosome profiling technology －Ribo-tRNA-seq reveals a novel mechanism of translation inhibition－ |
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| 2018.03.22 |  |
| Molecular basis for diversification of amyloid conformation －Structural fluctuation of monomeric protein determines amyloid conformation－ |
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| 2017.07.07 |  |
| Untangling depression in Huntington’s disease —Co-aggregation between huntingtin and a biological mediator of mental conditions elicits anhedonia— |
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| 2015.11.20 |  |
| Prion-like protein aggregates confer antiviral activity for cell survival －A prion-like [KIL-d] element induces viral inactivation via the “error catastrophe－ |
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